The Georgie project sends out periodic reports of our findings.  These reports are generally sent to the participants along with detailed information on their dogs.  Here we have reproduce the public versions of the report for your reference.  If you participated in a specific study and did not receive a report on your specific dog please contact the Georgie Project.

UPDATES

1997 SURVEY

In 1997 we conducted an extensive survey of 360 Portuguese Water Dogs.  We were trying to get an idea of which characteristics of the breed were varying.  These characterisitcs could then be used for genetic analysis.  Read the Survey results for more details.


Genetic founder analysis of Cardiomyopathy.

Geneitc founder analysis of GM1

ACTH study phase I report

X-ray study phase I report

Georgie Project Specialty Report 2001

Thyroid Study

GREAT VIDEO FOOTAGE OF THE GEORGIE PROJECT
        
        The Georgie project has been featured in a Daily Planet video.  EXN.ca has the video on their web site at
        http://www.exn.ca/Stories/2002/12/05/53.asp



PUBLICATIONS

Chase, K., Lawler, D.F., Carrier, D,R. and K.G. Lark (2005) Genetic
regulation of osteoarthritis: A QTL regulating cranial and caudal acetabular
osteophyte formation in the hip joint of the dog (Canis familiaris). Amer.
J. Med. Genet. 135A(3):334-335.
http://www3.interscience.wiley.com/cgi-bin/jtoc/33129/
 
Carrier DR, Chase K, Lark KG. Genetics of canid skeletal variation: size and
shape of the pelvis. Genome Res. 2005 Dec;15(12):1825-30.
PMID: 16339381 [PubMed - indexed for MEDLINE]
 
Chase K, Carrier DR, Adler FR, Ostrander EA, Lark KG. Interaction between
the X chromosome and an autosome regulates size sexual dimorphism in
Portuguese Water Dogs. Genome Res. 2005 Dec;15(12):1820-4.
PMID: 16339380 [PubMed - indexed for MEDLINE]
 
Lark, K.G., Chase, K., Carrier, D.R. and F.R. Adler (2005) Genetic analysis
of the canid skeleton: Analysis of morphological loci (QTLs) in the
Portuguese Water Dog population.  In: "The Genome of the Domestic Dog" (Cold
Spring Harbor Monograph Series 44). pp. 67-80. Editors: E.A. Ostrander, U.
Giger, and K. Lindblad-Toh. Cold Spring Harbor Press, Cold Spring Harbor,
NY.

Trut, L.N., Kharlamova, A.V., Carrier, D.R., Chase, K., Kukekova, A.V.,
Acland, G.M. and K.G. Lark (2005) Morphology and behavior: Are they coupled
at the genome level? In: "The Genome of the Domestic Dog² (Cold Spring
Harbor Monograph Series 44). pp. 81-93. Editors: E.A. Ostrander, U. Giger,
and K. Lindblad-Toh. Cold Spring Harbor Press, Cold Spring Harbor, NY.

Lark KG, Chase K, Sutter NB. Genetic architecture of the dog: sexual size
dimorphism and functional morphology. Trends Genet. 2006 Oct;22(10):537-44.
Epub 2006 Aug 24 PMID: 16934357 [PubMed - in process]

Chase K, Lawler DF, Adler FR, Ostrander EA, Lark KG.

Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris).
Am J Med Genet A. 2004 Jan 30;124(3):239-47.
PMID: 14708095 [PubMed - indexed for MEDLINE]

Chase K, Carrier DR, Adler FR, Jarvik T, Ostrander EA, Lorentzen TD, Lark KG.

Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton.
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9930-5. Epub 2002 Jul 11.
PMID: 12114542 [PubMed - indexed for MEDLINE]

Alroy J, Rush JE, Freeman L, Amarendhra Kumar MS, Karuri A, Chase K, Sarkar S.

Inherited infantile dilated cardiomyopathy in dogs: genetic, clinical, biochemical, and morphologic findings.
Am J Med Genet. 2000 Nov 6;95(1):57-66.
PMID: 11074496 [PubMed - indexed for MEDLINE]

Chase K, Adler FR, Miller-Stebbings K, Lark KG.

Teaching a new dog old tricks: identifying quantitative trait loci using lessons from plants.
J Hered. 1999 Jan-Feb;90(1):43-51.
PMID: 9987902 [PubMed - indexed for MEDLINE]